SIRT1 in Astrocytes Regulates Glucose Metabolism and Reproductive Function
نویسندگان
چکیده
منابع مشابه
Phosphorylation Regulates SIRT1 Function
BACKGROUND SIR2 is an NAD(+)-dependent deacetylase [1]-[3] implicated in the regulation of lifespan in species as diverse as yeast [4], worms [5], and flies [6]. We previously reported that the level of SIRT1, the mammalian homologue of SIR2 [7], [8], is coupled to the level of mitotic activity in cells both in vitro and in vivo[9]. Cells from long-lived mice maintained SIRT1 levels of young mi...
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*Department of Genetics and Complex Diseases, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115; ‡Howard Hughes Medical Institute, Gene Expression Laboratory, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037; Departments of §Biology and ¶Medicine, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093; Labo...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 2019
ISSN: 1945-7170
DOI: 10.1210/en.2019-00223